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Ab initio structure prediction

Part 4. Bioinformatics

4.6. Methods for Structure Analysis and Prediction

Specialist Review

  1. David Baker1,
  2. William R. Taylor2

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g406201

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Baker, D. and Taylor, W. R. 2005. Ab initio structure prediction. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:66.

Author Information

  1. 1

    University of Washington, Seattle, WA, USA

  2. 2

    National Institute for Medical Research, London, UK

Publication History

  1. Published Online: 15 NOV 2005

Abstract

The prediction of a folded protein structure from just its amino acid sequence (ab initio prediction) has been an outstanding problem in theoretical molecular biology for many years. Attempts based purely on physicochemical principles have had little success (except for short peptides), and a variety of approaches have been developed on the basis of the incorporation of known protein features to overcome this limitation. The most successful of these are based on building proteins from short fragments, and the performance of the ROSETTA program, which uses this method, is described.

Keywords:

  • protein structure prediction;
  • Rosetta method