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Threading for protein-fold recognition

Part 4. Bioinformatics

4.6. Methods for Structure Analysis and Prediction

Short Specialist Review

  1. Kuang Lin

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g406305

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Lin, K. 2005. Threading for protein-fold recognition. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:72.

Author Information

  1. National Institute for Medical Research, London, UK

Publication History

  1. Published Online: 15 APR 2005

Abstract

Protein three-dimensional structures, which provide vital biological information, can often be solved using X-ray crystallography and NMR techniques (Thornton et al., 1999; Orengo et al., 2001). These structure-solving techniques have been greatly improved in the last two decades. However, protein sequences from large-scale gene-sequencing projects are emerging at extraordinary rates. The gap between the number of known protein sequences and the known protein structures is continuously enlarging. Methods of predicting protein structure from its amino acid sequence are therefore of great importance to many biological researches.

Keywords:

  • structure prediction;
  • threading;
  • scoring function;
  • alignment;
  • profile