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Protein structure comparison

Part 4. Bioinformatics

4.6. Methods for Structure Analysis and Prediction

Short Specialist Review

  1. Liisa Holm

Published Online: 15 NOV 2005

DOI: 10.1002/047001153X.g406315

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Holm, L. 2005. Protein structure comparison. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:75.

Author Information

  1. University of Helsinki, Helsinki, Finland

Publication History

  1. Published Online: 15 NOV 2005

Abstract

Automatic methods of protein structure comparison allow similarities to be found between proteins that cannot be seen using just sequence data. This allows distant evolutionary relationships to be proposed and can help elucidate the function of a protein. The all-against-all comparison of known protein structures has allowed the structure of “fold-space” to be mapped, from broad general trends to specific clusters of proteins that have the same evolutionary origins. Collections can be found in databases accessible through the Internet. There are many practical methods for structure comparison using a variety of algorithms and similarity measures. There is no absolutely correct approach and the choice of method must be matched to the aspect of structure being investigated.