Protein structure comparison
Part 4. Bioinformatics
4.6. Methods for Structure Analysis and Prediction
Short Specialist Review
Published Online: 15 NOV 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
How to Cite
Holm, L. 2005. Protein structure comparison. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.6:75.
- Published Online: 15 NOV 2005
Automatic methods of protein structure comparison allow similarities to be found between proteins that cannot be seen using just sequence data. This allows distant evolutionary relationships to be proposed and can help elucidate the function of a protein. The all-against-all comparison of known protein structures has allowed the structure of “fold-space” to be mapped, from broad general trends to specific clusters of proteins that have the same evolutionary origins. Collections can be found in databases accessible through the Internet. There are many practical methods for structure comparison using a variety of algorithms and similarity measures. There is no absolutely correct approach and the choice of method must be matched to the aspect of structure being investigated.