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Design of KEGG and GO

Part 4. Bioinformatics

4.8. Modern Programming Paradigms in Biology

Short Specialist Review

  1. Minoru Kanehisa

Published Online: 15 APR 2005

DOI: 10.1002/047001153X.g409310

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics

How to Cite

Kanehisa, M. 2005. Design of KEGG and GO. Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics. 4:4.8:101.

Author Information

  1. Kyoto University, Kyoto, Japan

Publication History

  1. Published Online: 15 APR 2005

Abstract

The complete genome sequence contains the information about a repertoire of genes, which would enable the understanding of higher-level complexity of cellular functions and organismic phenotypes. The process of genome annotation, in which individual gene functions are assigned, should then be coupled with capturing collective features of higher-level biological systems. The two resources, KEGG (Kyoto Encyclopedia of Genes and Genomes) and GO (Gene Ontology), provide facilities for computational mapping of individual gene functions to higher-level systemic functions with different concepts and implementations.

Keywords:

  • database;
  • ontology;
  • graph;
  • genome annotation;
  • microarray analysis;
  • network analysis;
  • metabolic pathway;
  • chemical genomics