Standard Article

Clinical Trials Protocols

  1. Joseph F. Collins

Published Online: 15 JUL 2005

DOI: 10.1002/0470011815.b2a01008

Encyclopedia of Biostatistics

Encyclopedia of Biostatistics

How to Cite

Collins, J. F. 2005. Clinical Trials Protocols. Encyclopedia of Biostatistics. 2.

Author Information

  1. V.A. Medical Center, Perry Point, MD, USA

Publication History

  1. Published Online: 15 JUL 2005


A system is chaotic if it is governed by a set of deterministic equations, but displays erratic, apparently random, behavior. The mathematical structure may be the iteration of linked difference equations in discrete time, or the evolution of a set of linked differential equations in continuous time. Stochastic interpretations, especially those involving time series analysis, are described.


  • deterministic;
  • difference equation;
  • differential equation;
  • attractor;
  • fractal;
  • time series;
  • pseudo-random