Natural History Study of Prognosis
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Biostatistics
How to Cite
Cnaan, A. 2005. Natural History Study of Prognosis. Encyclopedia of Biostatistics.
- Published Online: 15 JUL 2005
Prognosis refers to the probable outcome of an attack of disease. The traditional definition would describe the evolution of disease in the absence of medical intervention, but nowadays we may also include the term “clinical course” to describe the natural history of a disease that has been affected by medical intervention. Various design considerations are reviewed for the study of natural history, including the use of cohort studies, the various biases that may affect such studies, and the definition of time zero as a clearly defined starting point. Other topics include the analysis of dichotomous outcomes, survival analysis and longitudinal data analysis. Combination of data from several studies, and situations involving multiple outcomes are also mentioned.
- study design;
- data analysis;
- data synthesis;
- multiple outcomes