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Vaccine Studies

  1. M. Elizabeth Halloran

Published Online: 15 JUL 2005

DOI: 10.1002/0470011815.b2a04058

Encyclopedia of Biostatistics

Encyclopedia of Biostatistics

How to Cite

Halloran, M. E. 2005. Vaccine Studies. Encyclopedia of Biostatistics. 8.

Author Information

  1. Emory University, Atlanta, GA, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

This entry begins with a brief overview of the biological background for vaccine action, and then describes the various phases of vaccine development, including early phases of identification of candidate vaccines, establishment of safety and immunogenicity in animals, safety and immunogenicity in humans, field efficacy trials, and post licensure studies. Measures of vaccine efficacy are described, and certain potential study biases are identified.

Keywords:

  • animal studies;
  • safety;
  • immunogenicity;
  • field trials;
  • vaccine efficacy;
  • postmarketing surveillance