Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Biostatistics
How to Cite
Chakravarti, A. 2005. Linkage Disequilibrium. Encyclopedia of Biostatistics. 4.
- Published Online: 15 JUL 2005
The nonrandom association between alleles at different loci is termed linkage disequilibrium. This note discusses the origin of this concept, its theoretical genetic basis, its estimation and tests of significance, and applications. Linkage disequilibrium studies are critical in human disease gene mapping and is now a major area of research with the availability of variation of the human genome sequence.
- allelic association;
- random mating;
- natural selection;
- disease gene mapping