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Immunotoxicology

  1. Christopher J. Portier,
  2. Dori Germolec

Published Online: 15 JUL 2005

DOI: 10.1002/0470011815.b2a06013

Encyclopedia of Biostatistics

Encyclopedia of Biostatistics

How to Cite

Portier, C. J. and Germolec, D. 2005. Immunotoxicology. Encyclopedia of Biostatistics. 4.

Author Information

  1. National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Immunotoxicology is the study of the response of the immune system to toxicological insults, which are usually induced by xenobiotics. Experiments are carried out in vitro or in vivo. These can be host resistance assays, which concern the ability of the immune system to protect the host from infectious agents and so on or they can be immune function assays, which measure the response of the immune system to a stimulus. The former are largely analyzed using methods for categorical data, whereas the latter usually involve very large counts and these are generally analyzed using methods for continuous data. There is current interest in using immunotoxicity data in risk assessment.

Keywords:

  • bioassays;
  • host resistance assays;
  • immune function assays;
  • immunology;
  • risk assessment;
  • toxicology;
  • xenobiotics