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Mutagenicity Study

  1. Walter W. Piegorsch

Published Online: 15 JUL 2005

DOI: 10.1002/0470011815.b2a06019

Encyclopedia of Biostatistics

Encyclopedia of Biostatistics

How to Cite

Piegorsch, W. W. 2005. Mutagenicity Study. Encyclopedia of Biostatistics. 5.

Author Information

  1. University of South Carolina, Columbia, SC, USA

Publication History

  1. Published Online: 15 JUL 2005

Abstract

Biometric methods are discussed for analyzing data from bioassays of mutagenic response. Emphasis is placed on the classic microbial system in environmental mutagenesis: the Ames/Salmonella microsome assay. The assay produces count data to quantify the mutational response; statistical issues of interest when analyzing such data include testing for extra-Poisson variability, trend testing for a dose response, and trend testing under a nonmonotone dose response.

Keywords:

  • Cochran–Armitage trend test;
  • DNA damage;
  • Fisher dispersion test;
  • generalized score statistic;
  • Jonckheere–Terpstra trend test;
  • mutagenesis;
  • overdispersion;
  • umbrella alternatives