Quality of Life and Survival Analysis
Published Online: 15 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd
Encyclopedia of Biostatistics
How to Cite
Olschewski, M. 2005. Quality of Life and Survival Analysis. Encyclopedia of Biostatistics. 6.
- Published Online: 15 JUL 2005
In clinical research, where time to a specific endpoint like, for example, death is of interest, methods of survival analysis are usually applied. In recent years, such research is more and more accompanied by the inclusion of the patients subjective assessment of treatment circumscribed by the term health-related quality of life (HQoL). In the analysis of HQoL, methods of longitudinal analysis of variance are adequate. In this chapter, we put emphasis on statistical analysis methods that allow a joint analysis of both quantity and quality of survival. The major approach here is defined by quality-adjusted survival (QAS) times. Conceptually, this means that the survival time of a patient is weighted according to his/her subjective assessment of that time. Advantages and limitations of such a joint analysis are discussed in relation to the separate analyses of the components.
- quality of life;
- survival analysis;
- quality-adjusted survival time;
- clinical trials;
- longitudinal data analysis;
- missing data