Chapter 1. What is Evidence?

  1. David Machin1,2,3 and
  2. Michael J. Campbell4

Published Online: 29 NOV 2005

DOI: 10.1002/0470012994.ch1

Design of Studies for Medical Research

Design of Studies for Medical Research

How to Cite

Machin, D. and Campbell, M. J. (2005) What is Evidence?, in Design of Studies for Medical Research, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470012994.ch1

Author Information

  1. 1

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore

  2. 2

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 3

    Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK

  4. 4

    Medical Statistics Group, Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK

Publication History

  1. Published Online: 29 NOV 2005
  2. Published Print: 11 FEB 2005

ISBN Information

Print ISBN: 9780470844953

Online ISBN: 9780470012994

SEARCH

Keywords:

  • evidence-based medicine (EBM);
  • Bradford-Hill criteria;
  • evidence-based health care (EBHC);
  • collecting the evidence;
  • Control of the ‘experiment’;
  • ‘preclinical and clinical’ studies;
  • ‘epidemiological’ studies;
  • double-blind randomised controlled trial (RCT);
  • community intervention design;
  • guidelines for reporting

Summary

This chapter contains sections titled:

  • Introduction

  • Evidence and Proof

  • Collecting the Evidence

  • Types of Study and Hierarchy of Designs

  • Biological Variability

  • Statistical Considerations

  • Informed Consent and Ethical Approval

  • The Study Protocol

  • Reporting

  • Technical Notes