Chapter 9. Phase III Trials

  1. David Machin1,2,3 and
  2. Michael J. Campbell4

Published Online: 29 NOV 2005

DOI: 10.1002/0470012994.ch9

Design of Studies for Medical Research

Design of Studies for Medical Research

How to Cite

Machin, D. and Campbell, M. J. (2005) Phase III Trials, in Design of Studies for Medical Research, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470012994.ch9

Author Information

  1. 1

    Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore

  2. 2

    UK Children's Cancer Study Group, University of Leicester, UK

  3. 3

    Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK

  4. 4

    Medical Statistics Group, Institute of General Practice and Primary Care, School of Health and Related Sciences, University of Sheffield, UK

Publication History

  1. Published Online: 29 NOV 2005
  2. Published Print: 11 FEB 2005

ISBN Information

Print ISBN: 9780470844953

Online ISBN: 9780470012994

SEARCH

Keywords:

  • randomised Phase III trials;
  • crossover trials;
  • ‘before-and-after’ study;
  • two-treatment–two-period crossover trial;
  • ‘carry-over’ and Drop-out;
  • two-group parallel design;
  • ‘non-inferiority’ trial;
  • cluster-randomised trials;
  • intra-cluster correlation (ICC)

Summary

This chapter contains sections titled:

  • Introduction

  • Crossover Trials

  • Parallel Groups

  • Cluster Trials

  • Technical Detail