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Chapter 6. The Biotechnological Exploitation of Heterologous Protein Production in Fungi

  1. Dr Kevin Kavanagh
  1. Dr Brendan Curran1,
  2. Dr Virginia Bugeja2

Published Online: 20 DEC 2005

DOI: 10.1002/0470015330.ch6

Fungi: Biology and Applications

Fungi: Biology and Applications

How to Cite

Curran, B. and Bugeja, V. (2005) The Biotechnological Exploitation of Heterologous Protein Production in Fungi, in Fungi: Biology and Applications (ed K. Kavanagh), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470015330.ch6

Editor Information

  1. Department of Biology, National University of Ireland, Maynooth, Co. Kildare, Ireland

Author Information

  1. 1

    School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK

  2. 2

    School of Natural Sciences, University of Hertfordshire, College Lane, Hatfield, Hertfordshire AL10 9AB, UK

Publication History

  1. Published Online: 20 DEC 2005
  2. Published Print: 15 APR 2005

ISBN Information

Print ISBN: 9780470867013

Online ISBN: 9780470015339

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Keywords:

  • heterologous gene expression systems;
  • DNA manipulation;
  • Saccharomyces cerevisiae;
  • YEp technology;
  • protease-deficient host strains;
  • methylotrophs yeast species;
  • basic gene cloning;
  • Reporter genes and growth on selective media;
  • heterologous signal transduction systems

Summary

This chapter contains sections titled:

  • Fungal biotechnology

  • Heterologous protein expression in fungi

  • Budding stars

  • Methylotrophic yeast species

  • Case study–hepatitis B vaccine–a billion dollar heterologous protein from yeast

  • Further biotechnological applications of expression technology

  • Conclusion

  • Further reading

  • Revision questions