Interaction of Cadherin with the Actin Cytoskeleton

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. W. James Nelson,
  2. Frauke Drees and
  3. Soichiro Yamada

Published Online: 7 OCT 2008

DOI: 10.1002/047001766X.ch13

Signalling Networks in Cell Shape and Motility: Novartis Foundation Symposium 269

Signalling Networks in Cell Shape and Motility: Novartis Foundation Symposium 269

How to Cite

Nelson, W. J., Drees, F. and Yamada, S. (2005) Interaction of Cadherin with the Actin Cytoskeleton, in Signalling Networks in Cell Shape and Motility: Novartis Foundation Symposium 269 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/047001766X.ch13

Author Information

  1. Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5435, USA

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 9 SEP 2005

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470011904

Online ISBN: 9780470017661

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Keywords:

  • cadherin clustering;
  • actin cytoskeleton;
  • protein–protein interactions;
  • cell–cell adhesion;
  • cadherin-mediated cell–cell adhesion;
  • a-actinin;
  • BIACORE plasmon resonance spectroscopy;
  • Arp2/3 complex and formins;
  • cadherin core complex

Summary

Cadherins regulate cell-cell adhesion throughout embryonic development and in the adult organism, and defects in cadherin expression and function are characteristic of many disease states including cancer. Although extracellular binding between cadherins specifies adhesion between cells, the strength of the interaction is thought to be regulated by cadherin clustering through reorganization of the actin cytoskeleton. Protein-protein interactions have been described that could link cadherins either directly or indirectly to the actin cytoskeleton. Here, we describe these protein interactions, and examine critically the evidence that they link cadherins to the actin cytoskeleton.