2. Lithium Treatment: Focus on Long-Term Prophylaxis

  1. Hagop S. Akiskal5 and
  2. Mauricio Tohen6,7
  1. Mogens Schou1,2 and
  2. Paul Grof3,4

Published Online: 31 MAY 2006

DOI: 10.1002/0470017953.ch2

Bipolar Psychopharmacotherapy: Caring for the Patient

Bipolar Psychopharmacotherapy: Caring for the Patient

How to Cite

Schou, M. and Grof, P. (2005) Lithium Treatment: Focus on Long-Term Prophylaxis, in Bipolar Psychopharmacotherapy: Caring for the Patient (eds H. S. Akiskal and M. Tohen), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470017953.ch2

Editor Information

  1. 5

    International Mood Center, Department of Psychiatry at the University of San Diego and Veterans Administration Medical Center, 3350 La Jolla Village Dr. (116-A), San Diego, CA 92161, USA

  2. 6

    McLean Hospital, Harvard Medical School, Belmont, MA, USA

  3. 7

    Lilly Research Laboratories, Eli Lilly & Co, 525 S. Meridian Street, Indianapolis, IN 46225, USA

Author Information

  1. 1

    The Psychiatric Hospital, Skovagervej 2, DK-8240 Risskov, Denmark

  2. 2

    Syrenvej 4, Risskov, DK-8240, Denmark

  3. 3

    Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, 1145 Carling Avenue, Ottawa, Ontario K2E 7L2, Canada

  4. 4

    Mood Disorders Center of Ottawa, Suite 301, 1929 Russell RD, Ottawa, Ontario, Canada.

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 11 NOV 2005

ISBN Information

Print ISBN: 9780470856079

Online ISBN: 9780470017951



  • long-term prophylaxis;
  • lithium as an antimanic drug;
  • non-blind mirror trial;
  • manic-depressive illness;
  • recurrent affective disorders;
  • placebo-controlled trials;
  • excessive motor activity;
  • lithium intoxication


This chapter contains sections titled:

  • Introduction

  • Cade's Pioneering Study

  • Discovery of the Prophylactic Action of Lithium

  • Debate

  • Concerns about Side Effects and Risks

  • Use during Pregnancy and Lactation

  • Are New and Better Prophylactic Agents about to Oust Lithium?

  • Prophylaxis in Recurrent Depressive Disorder

  • Combination Treatment

  • The Effect of Lithium on the Patients' Suicidal Behavior

  • Benefits of Prophylactic Lithium Treatment

  • Conclusion

  • References