3. Valproate: Clinical Pharmacological Profile

  1. Hagop S. Akiskal2 and
  2. Mauricio Tohen3,4
  1. Charles L. Bowden and
  2. Vivek Singh

Published Online: 31 MAY 2006

DOI: 10.1002/0470017953.ch3

Bipolar Psychopharmacotherapy: Caring for the Patient

Bipolar Psychopharmacotherapy: Caring for the Patient

How to Cite

Bowden, C. L. and Singh, V. (2005) Valproate: Clinical Pharmacological Profile, in Bipolar Psychopharmacotherapy: Caring for the Patient (eds H. S. Akiskal and M. Tohen), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470017953.ch3

Editor Information

  1. 2

    International Mood Center, Department of Psychiatry at the University of San Diego and Veterans Administration Medical Center, 3350 La Jolla Village Dr. (116-A), San Diego, CA 92161, USA

  2. 3

    McLean Hospital, Harvard Medical School, Belmont, MA, USA

  3. 4

    Lilly Research Laboratories, Eli Lilly & Co, 525 S. Meridian Street, Indianapolis, IN 46225, USA

Author Information

  1. Department of Psychiatry, Mail Code 7792, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio TX 78229–3900, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 11 NOV 2005

ISBN Information

Print ISBN: 9780470856079

Online ISBN: 9780470017951



  • valproate in bipolar disorder;
  • mania with depressive features;
  • bipolar depression;
  • placebo monotherapy study;
  • dysphoric and euphoric mania;
  • serum level-response relationships;
  • stress-regulated kinases


This chapter contains sections titled:

  • Mania

  • Combination Treatment

  • Factors Associated with Acute Response to Valproate

  • Depression

  • Maintenance Treatment for Bipolar Disorder

  • Factors Associated with Response in Maintenance Treatment

  • Tolerability

  • Effects on Suicidality

  • Mechanisms of Action

  • Summary

  • References