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Chapter 15. Protein Interaction–Targeted Drug Discovery

  1. Ralph Rapley3,
  2. Stuart Harbron4
  1. Gary Hudes1,
  2. Sanjay Menon2,
  3. Erica A. Golemis1

Published Online: 27 SEP 2005

DOI: 10.1002/0470020202.ch15

Book Title

Molecular Analysis and Genome Discovery

Molecular Analysis and Genome Discovery

Additional Information

How to Cite

Hudes, G., Menon, S. and Golemis, E. A. (2005) Protein Interaction–Targeted Drug Discovery, in Molecular Analysis and Genome Discovery (eds R. Rapley and S. Harbron), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470020202.ch15

Editor Information

  1. 3

    University of Hertfordshire, UK

  2. 4

    The Enzyme Technology Consultancy, UK

Author Information

  1. 1

    Division of Medical Science, Fox Chase Cancer Center, 8801 Burholme Ave., Philadelphia, PA 19111, USA

  2. 2

    Morphochem Inc., Monmouth Junction, NJ 08852, USA

Publication History

  1. Published Online: 27 SEP 2005
  2. Published Print: 23 APR 2004

ISBN Information

Print ISBN: 9780471499190

Online ISBN: 9780470020203

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CHAPTER TOOLS

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Keywords:

  • protein–protein interactions (PPIs);
  • small ubiquitin-related modifier (SUMO);
  • farnesyltransferase inhibitors (FTIs);
  • cytostatic agents;
  • epidermal growth factor receptor (EGFr);
  • neurofibromatosis type 1 (NF-1);
  • pleiotropic effects

Summary

This chapter contains sections titled:

  • Introduction

  • PPIs: classes, functional relationships and regulation

  • Protein interactions in disease-related signalling: categories of disruption

  • Selecting targets and screens

  • Progress in cancer treatment

  • Summary

  • References

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