11. NMR Studies of Bioenergetic Impairment in Human Epilepsy

  1. Robert G. Shulman4 and
  2. Douglas L. Rothman5
  1. Hoby P. Hetherington1,
  2. Jullie W. Pan2 and
  3. Dennis D. Spencer3

Published Online: 18 AUG 2005

DOI: 10.1002/0470020520.ch11

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

How to Cite

Hetherington, H. P., Pan, J. W. and Spencer, D. D. (2004) NMR Studies of Bioenergetic Impairment in Human Epilepsy, in Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine (eds R. G. Shulman and D. L. Rothman), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470020520.ch11

Editor Information

  1. 4

    Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

  2. 5

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

Author Information

  1. 1

    Departments of Radiology, Physiology and Biophysics, Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461, USA

  2. 2

    Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461, USA

  3. 3

    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208082, New Haven, CT 08520-8082, USA

Publication History

  1. Published Online: 18 AUG 2005
  2. Published Print: 29 MAR 2004

ISBN Information

Print ISBN: 9780470847206

Online ISBN: 9780470020524

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Keywords:

  • bioenergetic impairment;
  • epilepsy;
  • epileptogenic tissue;
  • occipital gray matter;
  • parietal white matter;
  • glial fibrillary acidic protein (GFAP);
  • hippocampal tissue culture;
  • bioenergetic alterations

Summary

This chapter contains sections titled:

  • Introduction

  • 1H Spectroscopic Localization and Lateralization of Epileptogenic Regions

  • Factors Affecting Sensitivity and Specificity

  • Interpretation of Decreases in NAA Levels

  • 31P Spectroscopic Measurements of Bioenergetics in Human Epilepsy

  • Factors Affecting the Interpretation of 31P Data

  • Interpretation of the Bioenergetic Alterations

  • Possible Mechanism Linking Bioenergetic Impairment and Seizures

  • References