12. MRS Studies of the Role of Altered Glutamate and GABA Neurotransmitter Metabolism in the Pathophysiology of Epilepsy

  1. Robert G. Shulman3 and
  2. Douglas L. Rothman4
  1. Ognen A. C. Petroff1 and
  2. Dennis D. Spencer2

Published Online: 18 AUG 2005

DOI: 10.1002/0470020520.ch12

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

How to Cite

Petroff, O. A. C. and Spencer, D. D. (2004) MRS Studies of the Role of Altered Glutamate and GABA Neurotransmitter Metabolism in the Pathophysiology of Epilepsy, in Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine (eds R. G. Shulman and D. L. Rothman), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470020520.ch12

Editor Information

  1. 3

    Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

  2. 4

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

Author Information

  1. 1

    Yale University School of Medicine, Department of Neurology, P.O. Box 208018, New Haven, CT 06520-8018, USA

  2. 2

    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, P.O. Box 208082, New Haven, CT 08520-8082, USA

Publication History

  1. Published Online: 18 AUG 2005
  2. Published Print: 29 MAR 2004

ISBN Information

Print ISBN: 9780470847206

Online ISBN: 9780470020524

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Keywords:

  • temporal lobe epilepsy (TLE);
  • hippocampal sclerosis (HS);
  • epileptogenic zone;
  • phosphate-activated glutaminase (PAG);
  • glial proliferation;
  • extracellular fluid (ECF);
  • idiopathic generalized epilepsies

Summary

This chapter contains sections titled:

  • Introduction

  • Part I: MRS Studies of the Role of Astroglial Metabolism in Temporal Lobe Epilepsy

  • Part II: MRS Studies of the Role of GABA in Epilepsy

  • Conclusion: Alteration of Metabolism in Localization Related Epilepsies and Significance for Epileptogenicity

  • Acknowledgements

  • References