6. NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways

  1. Robert G. Shulman2 and
  2. Douglas L. Rothman3
  1. Kevin L. Behar1 and
  2. Douglas L. Rothman3

Published Online: 18 AUG 2005

DOI: 10.1002/0470020520.ch6

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

How to Cite

Behar, K. L. and Rothman, D. L. (2005) NMR Studies of the Metabolism and Energetics of GABA Neurotransmitter Pathways, in Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine (eds R. G. Shulman and D. L. Rothman), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470020520.ch6

Editor Information

  1. 2

    Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

  2. 3

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

Author Information

  1. 1

    Department of Psychiatry, Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

  2. 3

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

Publication History

  1. Published Online: 18 AUG 2005
  2. Published Print: 29 MAR 2004

ISBN Information

Print ISBN: 9780470847206

Online ISBN: 9780470020524

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Keywords:

  • gamma-aminobutyric acid (GABA);
  • GABA transporters (GATs);
  • glutamate neurotransmitter pathways;
  • glutamate decarboxylase (GAD);
  • glutamine transporters;
  • quantitative NMR studies

Summary

This chapter contains sections titled:

  • Introduction

  • Neuronal Localization of GABA

  • Pathways of Brain GABA Synthesis and Catabolism

  • Role of GABA and Glutamine Transporters in GABA Metabolism

  • NMR Studies of GABAergic Function

  • NMR Studies of GABA Synthesis Regulation In vivo

  • Conclusions

  • References