8. Imaging Cerebral Metabolic Rate of Oxygen Consumption (CMRO2) Using 17O NMR Approach at Ultrahigh Field

  1. Robert G. Shulman3 and
  2. Douglas L. Rothman4
  1. Wei Chen1,
  2. Xiao-Hong Zhu2 and
  3. Kamil Ugurbil2

Published Online: 18 AUG 2005

DOI: 10.1002/0470020520.ch8

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine

How to Cite

Chen, W., Zhu, X.-H. and Ugurbil, K. (2005) Imaging Cerebral Metabolic Rate of Oxygen Consumption (CMRO2) Using 17O NMR Approach at Ultrahigh Field, in Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine (eds R. G. Shulman and D. L. Rothman), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470020520.ch8

Editor Information

  1. 3

    Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

  2. 4

    Department of Diagnostic Radiology, Yale University School of Medicine, MR Center, P.O. Box 208043, New Haven, CT 06520-8043, USA

Author Information

  1. 1

    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA, tel: 612-625-8814

  2. 2

    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA

Publication History

  1. Published Online: 18 AUG 2005
  2. Published Print: 29 MAR 2004

ISBN Information

Print ISBN: 9780470847206

Online ISBN: 9780470020524

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Keywords:

  • oxidative metabolism;
  • mitochondrial respiratory chain;
  • adenosine triphosphate (ATP);
  • blood oxygen level dependent (BOLD);
  • signal-to-noise ratio (SNR);
  • relative signal fluctuations;
  • vasomotion

Summary

This chapter contains sections titled:

  • Central Role of Oxidative Metabolism in Brain Function and Brain Diseases

  • Existing Methodologies for Determining CMRO2in vivo

  • 17O NMR Approaches and CMRO2 Measurements

  • Increased 17O NMR Sensitivity at Ultrahigh Fields

  • Advantages of Direct17O NMR Approach for Imaging CMRO2

  • Ultrahigh Field 17O NMR Approach for Imaging CMRO2

  • Conclusions and Perspectives

  • Acknowledgments

  • References