Chapter 1. Metals in Brain, Metal Transport, Storage and Homeostasis

  1. Robert R. Crichton and
  2. Roberta J. Ward

Published Online: 17 MAY 2006

DOI: 10.1002/0470022574.ch1

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. R. and Ward, R. J. (2005) Metals in Brain, Metal Transport, Storage and Homeostasis, in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470022574.ch1

Author Information

  1. Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 17 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9780470022559

Online ISBN: 9780470022573

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Keywords:

  • metal ions in brain function;
  • oestrogen-dependent pathway;
  • memory molecule;
  • redox-active metals;
  • labile iron pool (LIP);
  • iron responsive proteins (IRP);
  • protein degradation;
  • lysosomal mechanisms;
  • ATP-dependent cytosol

Summary

This chapter contains sections titled:

  • Introduction – the importance of metal ions in brain function

  • Metal ion transport and storage – iron

  • Metal ion transport and storage – copper

  • Metal ion transport and storage – zinc

  • Metal ion transport and storage – other metals

  • Metals and their homeostasis (with particular reference to iron and copper)

  • References