Chapter 2. Oxidative Stress and Redox-Active Metal Ions

  1. Robert R. Crichton and
  2. Roberta J. Ward

Published Online: 17 MAY 2006

DOI: 10.1002/0470022574.ch2

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. R. and Ward, R. J. (2005) Oxidative Stress and Redox-Active Metal Ions, in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470022574.ch2

Author Information

  1. Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 17 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9780470022559

Online ISBN: 9780470022573

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Keywords:

  • oxygen-rich environment;
  • oxygen paradox;
  • reactive oxygen species (ROS);
  • Fenton reaction;
  • reactive nitrogen species;
  • lipid peroxidation;
  • advanced glycation end products;
  • mitochondria;
  • apoptosis

Summary

This chapter contains sections titled:

  • Introduction – the oxygen paradox

  • Reactive oxygen species (ROS)

  • Reactive nitrogen species (RNS)

  • The targets of ROS and RNS

  • Cytoprotection against oxidative damage

  • Mitochondria, free radicals and signalling

  • Cyclin-dependent kinases

  • Apoptosis – programmed cell death

  • ROS, RNS and signal transduction

  • Molecules involved in the inflammatory pathway

  • References