Chapter 5. Huntington's Disease and Polyglutamine Expansion Neurodegenerative Diseases

  1. Robert R. Crichton and
  2. Roberta J. Ward

Published Online: 17 MAY 2006

DOI: 10.1002/0470022574.ch5

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. R. and Ward, R. J. (2005) Huntington's Disease and Polyglutamine Expansion Neurodegenerative Diseases, in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470022574.ch5

Author Information

  1. Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 17 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9780470022559

Online ISBN: 9780470022573

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Keywords:

  • triplet expansion;
  • amyotrophic lateral sclerosis;
  • aggregation efficiency;
  • neuronal damage;
  • cell death;
  • Huntington's disease;
  • heat-shock proteins

Summary

This chapter contains sections titled:

  • Introduction – an overview of trinucleotide expansion diseases

  • PolyQ diseases

  • Structural models of polyQ protein aggregation

  • Mechanisms of cell death in polyQ diseases

  • Huntington's disease

  • Other polyQ disease proteins

  • References