Chapter 7. Creutzfeldt-Jakob and Other Prion Diseases

  1. Robert R. Crichton and
  2. Roberta J. Ward

Published Online: 17 MAY 2006

DOI: 10.1002/0470022574.ch7

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies

How to Cite

Crichton, R. R. and Ward, R. J. (2005) Creutzfeldt-Jakob and Other Prion Diseases, in Metal-based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470022574.ch7

Author Information

  1. Université Catholique de Louvain, Belgium

Publication History

  1. Published Online: 17 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9780470022559

Online ISBN: 9780470022573

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Keywords:

  • transmissible spongiform encephalopathies (TSEs);
  • fatal familial insomnia;
  • prion behaviour;
  • neurodegenerative diseases;
  • peripheral replication;
  • lymphoreticular system;
  • follicular dendritic cells;
  • copper transport proteins

Summary

This chapter contains sections titled:

  • Introduction

  • A brief history of prion diseases

  • The ‘prion’ or ‘protein-only’ hypothesis and conformation-based prion inheritance

  • Mechanism of conformation-based prion transmission

  • Pathways of prion pathogenesis

  • Prion-metal interactions

  • References