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Chapter

The Transmission/Disequilibrium Test

  1. W.J. Ewens1,
  2. R.S. Spielman2

Published Online: 15 JUL 2004

DOI: 10.1002/0470022620.bbc33

Book Title

Handbook of Statistical Genetics

Handbook of Statistical Genetics

Additional Information

How to Cite

Ewens, W.J. and Spielman, R.S. 2004. The Transmission/Disequilibrium Test. Handbook of Statistical Genetics.

Author Information

  1. 1

    University of Pennsylvania, Departments of Biology, USA

  2. 2

    University of Pennsylvania, Department of Genetics, USA

Publication History

  1. Published Online: 15 JUL 2004
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The transmission-disequilibrium test (TDT) is an association-based test for linkage. It is a family-based test and thus avoids the problems potentially arising in case–control tests from population stratification. However it does this at some loss of power. Various other positive and negative features of the test are examined from a quantitative viewpoint.

Keywords: transmission-disequilibrium test; linkage; association; power; marker alleles; chi-square tests

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