Chapter 13. Pharmacology of Acetylenic Derivatives

  1. Professor Saul Patai
  1. Zvi Ben-Zvi and
  2. Abraham Danon

Published Online: 29 JUL 2004

DOI: 10.1002/0470024771.ch13

Triple Bonded Functional Groups (1994)

Triple Bonded Functional Groups (1994)

How to Cite

Ben-Zvi, Z. and Danon, A. (1994) Pharmacology of Acetylenic Derivatives, in Triple Bonded Functional Groups (1994) (ed S. Patai), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470024771.ch13

Editor Information

  1. The Hebrew University, Jerusalem, Israel

Author Information

  1. Department of Clinical Pharmacology, Ben-Gurion University of the Negev and Soroka Medical Center, Beer Sheva, Israel

Publication History

  1. Published Online: 29 JUL 2004
  2. Published Print: 31 OCT 1994

Book Series:

  1. PATAI'S Chemistry of Functional Groups

Book Series Editors:

  1. Professor Saul Patai and
  2. Professor Zvi Rappoport

Series Editor Information

  1. The Hebrew University, Jerusalem, Israel

ISBN Information

Print ISBN: 9780471935599

Online ISBN: 9780470024775



This chapter contains sections titled:

  • Introduction

  • Metabolic Degradation of Acetylenic Drugs

    • Metabolism of α-acetylenic Steroids

    • Conjugation Reactions

  • Oral Contraceptive Steroids

    • Adverse Reactions

  • Deactivation of Cytochrome P450 by Acetylenes

    • Mechanism of Cytochrome P450 Deactivation

    • Inhibition of Cytochrome P450 Isozyme Families 756

      • Inhibition of Cytochrome P450 1A

      • Inhibition of Cytochrome P450 3A

      • Inhibition of Cytochrome P450 22A

      • Inhibition of Aromatase

  • Propargylamine Derivatives

    • Monoamine Oxidase (MAO)

    • Propargylamine MAO Inhibitors

    • Pharmacological Properties of Chlorgyline

    • Pharmacological Properties of Selegiline

      • Therapeutic Uses

      • Adverse Reactions

    • Structure-activity Relationship of Propargylamine Derivatives

    • Metabolism of Propargylamine Derivatives

      • Metabolism of Selegiline

      • Pharmacokinetics of Selegiline

      • Metabolism of Pargyline

  • Acetylenic Fatty Acids

  • Thymidylate Synthetase Inhibition by Propargyl Analogs of Folic Acid

  • Cholinergic Muscarinic Agents

    • Oxotremorine Analogs

    • Arecaidine Propargyl Esters

  • Acknowledgments

  • References