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Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour Platinum-Based Drugs

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  1. Zahid H. Siddik

Published Online: 15 JAN 2005

DOI: 10.1002/0470025077.chap84b

The Cancer Handbook

The Cancer Handbook

How to Cite

Siddik, Z. H. 2005. Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA-Interactive Alkylating Agents and Antitumour Platinum-Based Drugs. The Cancer Handbook. .

Author Information

  1. The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

Publication History

  1. Published Online: 15 JAN 2005

First page of article

First page of Mechanisms of Action of Cancer Chemotherapeutic Agents: DNA‐Interactive Alkylating Agents and Antitumour Platinum‐Based Drugs

Keywords:

  • alkylating agents;
  • monofunctional agents;
  • bifunctional agents;
  • aziridines;
  • nitrogen mustards;
  • alkyl sulfonates;
  • chloroethylnitrosoureas;
  • platinum agents;
  • drug activation;
  • mechanism of action;
  • interstrand cross-link;
  • intrastrand cross-link;
  • DNA damage recognition protein;
  • tumour suppressor p53;
  • apoptosis