10. Iron and its Role in Neurodegenerative Diseases

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Roberta J. Ward and
  2. Robert R. Crichton

Published Online: 27 JUL 2006

DOI: 10.1002/0470028114.ch10

Neurodegenerative Diseases and Metal Ions, Volume 1

Neurodegenerative Diseases and Metal Ions, Volume 1

How to Cite

Ward, R. J. and Crichton, R. R. (2006) Iron and its Role in Neurodegenerative Diseases, in Neurodegenerative Diseases and Metal Ions, Volume 1 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470028114.ch10

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Unité de Biochimie, Université Catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium

Publication History

  1. Published Online: 27 JUL 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780470014882

Online ISBN: 9780470028117

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Keywords:

  • iron inorganic chemistry;
  • labile iron pool in free radical production;
  • iron significance in brain;
  • brain iron as function of age;
  • iron in neurodegenerative diseases;
  • brain iron loading approach;
  • Hallervorden–Spatz Syndrome

Summary

This chapter contains sections titled:

  • Introduction

  • The Inorganic Chemistry of Iron and Its Role in Human Biology

  • Iron Metabolism

  • The Role of the ‘Labile Iron Pool’ in Free Radical Production

  • The Importance of Iron in Brain

  • The Involvement of Iron in Neurodegenerative Diseases

  • Experimental Approaches to Brain Iron Loading

  • Conclusions

  • Acknowledgments

  • Abbreviations

  • References