2. Protein Folding, Misfolding, and Disease

  1. Astrid Sigel2,
  2. Helmut Sigel2 and
  3. Roland K. O. Sigel3
  1. Jennifer C. Lee,
  2. Judy E. Kim,
  3. Ekaterina V. Pletneva,
  4. Jasmin Faraone-Mennella,
  5. Harry B. Gray and
  6. Jay R. Winkler

Published Online: 27 JUL 2006

DOI: 10.1002/0470028114.ch2

Neurodegenerative Diseases and Metal Ions, Volume 1

Neurodegenerative Diseases and Metal Ions, Volume 1

How to Cite

Lee, J. C., Kim, J. E., Pletneva, E. V., Faraone-Mennella, J., Gray, H. B. and Winkler, J. R. (2006) Protein Folding, Misfolding, and Disease, in Neurodegenerative Diseases and Metal Ions, Volume 1 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470028114.ch2

Editor Information

  1. 2

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 3

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA

Publication History

  1. Published Online: 27 JUL 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780470014882

Online ISBN: 9780470028117



  • protein folding dynamics;
  • photochemical electron transfer triggers;
  • partially folded polypeptide structures;
  • protein folding, misfolding and disease;
  • electron transfer kinetics;
  • denatured state;
  • cytochrome c folding landscapes;
  • FET and ET kinetics of amyloidogenic peptides


This chapter contains sections titled:

  • Introduction

  • Experimental Methods

  • The Denatured State

  • Protein Folding Dynamics

  • α-Synuclein and Parkinson's Disease

  • Conclusions and Outlook

  • Acknowledgments

  • Abbreviations and Definitions

  • References