3. Metal Ion Binding Properties of Proteins Related to Neurodegeneration

  1. Astrid Sigel3,
  2. Helmut Sigel3 and
  3. Roland K. O. Sigel4
  1. Henryk Kozlowski1,
  2. Marek Luczkowski1,
  3. Daniela Valensin2 and
  4. Gianni Valensin2

Published Online: 27 JUL 2006

DOI: 10.1002/0470028114.ch3

Neurodegenerative Diseases and Metal Ions, Volume 1

Neurodegenerative Diseases and Metal Ions, Volume 1

How to Cite

Kozlowski, H., Luczkowski, M., Valensin, D. and Valensin, G. (2006) Metal Ion Binding Properties of Proteins Related to Neurodegeneration, in Neurodegenerative Diseases and Metal Ions, Volume 1 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470028114.ch3

Editor Information

  1. 3

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 4

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland

  2. 2

    Department of Chemistry, University of Siena, Via Aldo Moro, I-53100 Siena, Italy

Publication History

  1. Published Online: 27 JUL 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780470014882

Online ISBN: 9780470028117

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Keywords:

  • CuM2+ interactions with mammalian prion;
  • metal ion interaction with amyloid;
  • precursor protein and fragments;
  • metal ion binding sites in cysteine region;
  • amyloid precursor protein (APP) and prion protein (PrPc);
  • mammalian prion proteins and potential metal ion binding site;
  • metal ions, proteins and neurodegeneration;
  • amyloid precursor protein (APP) role in AD

Summary

This chapter contains sections titled:

  • Introduction

  • Cu2+ Interactions with Mammalian Prion Proteins and Their Fragments

  • Interactions of Metal Ions with the Amyloid Precursor Protein and Its Fragments

  • Concluding Remarks

  • Acknowledgments

  • Abbreviations

  • References