5. The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease

  1. Astrid Sigel3,
  2. Helmut Sigel3 and
  3. Roland K. O. Sigel4
  1. Thomas A. Bayer1 and
  2. Gerd Multhaup2

Published Online: 27 JUL 2006

DOI: 10.1002/0470028114.ch5

Neurodegenerative Diseases and Metal Ions, Volume 1

Neurodegenerative Diseases and Metal Ions, Volume 1

How to Cite

Bayer, T. A. and Multhaup, G. (2006) The Role of Metal Ions in the Amyloid Precursor Protein and in Alzheimer's Disease, in Neurodegenerative Diseases and Metal Ions, Volume 1 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470028114.ch5

Editor Information

  1. 3

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 4

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Universität des Saarlandes, Klinik für Psychiatrie, Abteilung für Neurobiologie, D-66421 Homburg/Saar, Germany

  2. 2

    Institut für Chemie/Biochemie, Freie Universität Berlin, Thielallee 63, D-14195 Berlin, Germany

Publication History

  1. Published Online: 27 JUL 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780470014882

Online ISBN: 9780470028117

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Keywords:

  • amyloid precursor protein and brain copper homeostasis;
  • Alzheimer's disease (AD);
  • amyloid precursor protein (APP);
  • N-terminal Cu binding domain (CuBD-I) of APP;
  • metal ion in amyloid precursor protein;
  • APP in Cu homeostasis in man

Summary

This chapter contains sections titled:

  • Introduction

  • Amyloid Precursor Protein and Brain Copper Homeostasis

  • Amyloid Precursor Protein and Cu,Zn-Superoxide Dismutase-1

  • General Conclusions

  • Abbreviations

  • References