7. In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases

  1. Astrid Sigel6,
  2. Helmut Sigel6 and
  3. Roland K. O. Sigel7
  1. George Bartzokis1,2,3,4,
  2. Po H. Lu1,3,
  3. Todd A. Tishler1,3,5 and
  4. Susan Perlman1

Published Online: 27 JUL 2006

DOI: 10.1002/0470028114.ch7

Neurodegenerative Diseases and Metal Ions, Volume 1

Neurodegenerative Diseases and Metal Ions, Volume 1

How to Cite

Bartzokis, G., Lu, P. H., Tishler, T. A. and Perlman, S. (2006) In Vivo Assessment of Iron in Huntington's Disease and Other Age-Related Neurodegenerative Brain Diseases, in Neurodegenerative Diseases and Metal Ions, Volume 1 (eds A. Sigel, H. Sigel and R. K. O. Sigel), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470028114.ch7

Editor Information

  1. 6

    Department of Chemistry, Inorganic Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland

  2. 7

    Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland

Author Information

  1. 1

    Department of Neurology, Alzheimer's Disease Center, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095–1769, USA

  2. 2

    Laboratory of Neuroimaging, Department of Neurology, Division of Brain Mapping, UCLA, Los Angeles, CA 90095, USA

  3. 3

    Greater Los Angeles VA Healthcare System, Department of Psychiatry, West Los Angeles, CA 90073, USA

  4. 4

    Department of Psychiatry, Charles R. Drew University of Medicine and Science, Los Angeles, CA USA90043, USA

  5. 5

    Neuroscience Interdepartmental Graduate Program, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Publication History

  1. Published Online: 27 JUL 2006
  2. Published Print: 24 MAR 2006

ISBN Information

Print ISBN: 9780470014882

Online ISBN: 9780470028117

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Keywords:

  • oligodendrocytes and iron in brain;
  • elevated iron and exacerbation of excitotoxicity;
  • human brain and disease phenotypes;
  • transition metal metabolism and proteinopathies;
  • in vivo brain iron measurement;
  • myelinated projection neuron toxicity;
  • novel treatment consideration;
  • Huntington and brain iron homeostasis

Summary

This chapter contains sections titled:

  • Introduction. Puzzling Changes in Cell Numbers in Huntington's Disease Brain

  • Human Brain Development and Disease Phenotypes

  • Oligodendrocytes and Iron in Brain Development and Degeneration

  • Transition Metal Metabolism and Proteinopathies

  • In Vivo Measurement of Brain Iron

  • Novel Treatment Considerations

  • Conclusions

  • Acknowledgments

  • Abbreviations

  • References