Published Online: 15 APR 2006
Copyright © 2006 John Wiley & Sons, Ltd. All rights reserved.
Handbook of Metalloproteins
How to Cite
Matthews, B. W. 2006. Methionine Aminopeptidase. Handbook of Metalloproteins.
- Published Online: 15 APR 2006
The methionine aminopeptidases represent a novel class of metalloprotease generally having two cobalt ions in the active site. The proteins consist of two topologically similar domains folded with a pita-bread motif. Structural analysis of various inhibitor complexes with the Escherichia coli enzyme and other members of the family have suggested a putative mechanism of catalysis related to that originally proposed for thermolysin.3D Structure
Keywords: methionine aminopeptidase; cobalt; cancer; fumagillin; bestatin; thermolysin