Chapter 11. Today's Science, Tomorrow's Patient: the Pivotal Role of Tissue, Clinical Data and Informatics in Modern Drug Development

  1. Sylvia Nagl
  1. Kirstine Knox1,
  2. Amanda Taylor2 and
  3. David J. Kerr3

Published Online: 16 MAY 2006

DOI: 10.1002/0470032898.ch11

Cancer Bioinformatics: From Therapy Design to Treatment

Cancer Bioinformatics: From Therapy Design to Treatment

How to Cite

Knox, K., Taylor, A. and Kerr, D. J. (2006) Today's Science, Tomorrow's Patient: the Pivotal Role of Tissue, Clinical Data and Informatics in Modern Drug Development, in Cancer Bioinformatics: From Therapy Design to Treatment (ed S. Nagl), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470032898.ch11

Editor Information

  1. Department of Oncology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK

Author Information

  1. 1

    NTRAC Coordinating Centre, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK

  2. 2

    Cancer Services, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK

  3. 3

    Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, Oxford OX1 3PR, UK

Publication History

  1. Published Online: 16 MAY 2006
  2. Published Print: 27 JAN 2006

ISBN Information

Print ISBN: 9780470863046

Online ISBN: 9780470032893

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Keywords:

  • National Cancer Research Institute (NCRI);
  • NCRI National Cancer Tissue Resource (NCTR);
  • NCTR central bioinformatics platform;
  • proposed information system architecture;
  • e-Government Interoperability Framework (e-GIF)-compliant clinical information system;
  • NCRI Informatics Strategic Framework;
  • Multi-centre Research Ethics Committee (MREC);
  • consent and confidentiality

Summary

This chapter contains sections titled:

  • Introduction

  • A new national strategy for the provision of tissue annotated with clinical information to meet current and future needs of academic researchers and industry

  • The NCRI National Cancer Tissue Resource for cancer biology and treatment development

  • A potential future world-class resource integrating research and health service information systems and bioinformatics for cancer diagnosis and treatment

  • A proposed information system architecture that will meet the challenges and deliver the required functionality: an overview

  • Consent and confidentiality: ensuring that the NCTR is embedded in the UK's legal and ethical framework

  • Concluding remarks: future challenges and opportunities