Chapter 2. Theory of Cancer Robustness

  1. Sylvia Nagl
  1. Hiroaki Kitano

Published Online: 16 MAY 2006

DOI: 10.1002/0470032898.ch2

Cancer Bioinformatics: From Therapy Design to Treatment

Cancer Bioinformatics: From Therapy Design to Treatment

How to Cite

Kitano, H. (2006) Theory of Cancer Robustness, in Cancer Bioinformatics: From Therapy Design to Treatment (ed S. Nagl), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470032898.ch2

Editor Information

  1. Department of Oncology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK

Author Information

  1. The Systems Biology Institute, Suite 6A, M31 6-31-15 Jingumae, Shibuya, Tokyo 150-0001, Japan

Publication History

  1. Published Online: 16 MAY 2006
  2. Published Print: 27 JAN 2006

ISBN Information

Print ISBN: 9780470863046

Online ISBN: 9780470032893

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Keywords:

  • cancer robustness theory;
  • phage fate decision switching;
  • bacterial chemotaxis;
  • extensive system control;
  • phenotypic plasticity;
  • decoupling;
  • intratumoural genetic heterogeneity;
  • molecular-targeted drugs;
  • computational approach

Summary

This chapter contains sections titled:

  • Robustness: the fundamental organizational principle of biological systems

  • Underlying mechanisms for robustness

  • Intrinsic features of robust systems: evolvability and trade-offs

  • Cancer as a robust system

  • Therapy strategies

  • A proper index of treatment efficacy

  • Computational tools

  • Conclusion