Chapter 2. Theory of Cancer Robustness
- Sylvia Nagl
Published Online: 16 MAY 2006
DOI: 10.1002/0470032898.ch2
Copyright © 2006 John Wiley & Sons, Ltd
Book Title
Cancer Bioinformatics: From Therapy Design to Treatment
Additional Information
How to Cite
Kitano, H. (2006) Theory of Cancer Robustness, in Cancer Bioinformatics: From Therapy Design to Treatment (ed S. Nagl), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470032898.ch2
Editor Information
Department of Oncology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Publication History
- Published Online: 16 MAY 2006
- Published Print: 27 JAN 2006
ISBN Information
Print ISBN: 9780470863046
Online ISBN: 9780470032893
- Summary
- Chapter
Keywords:
- cancer robustness theory;
- phage fate decision switching;
- bacterial chemotaxis;
- extensive system control;
- phenotypic plasticity;
- decoupling;
- intratumoural genetic heterogeneity;
- molecular-targeted drugs;
- computational approach
Summary
This chapter contains sections titled:
Robustness: the fundamental organizational principle of biological systems
Underlying mechanisms for robustness
Intrinsic features of robust systems: evolvability and trade-offs
Cancer as a robust system
Therapy strategies
A proper index of treatment efficacy
Computational tools
Conclusion