Chapter 7. Structural Bioinformatics in Cancer

  1. Sylvia Nagl
  1. Stephen Neidle

Published Online: 16 MAY 2006

DOI: 10.1002/0470032898.ch7

Cancer Bioinformatics: From Therapy Design to Treatment

Cancer Bioinformatics: From Therapy Design to Treatment

How to Cite

Neidle, S. (2006) Structural Bioinformatics in Cancer, in Cancer Bioinformatics: From Therapy Design to Treatment (ed S. Nagl), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470032898.ch7

Editor Information

  1. Department of Oncology, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK

Author Information

  1. The School of Pharmacy, University of London, 26-39 Brunswick Square, London WC1N 1AX, UK

Publication History

  1. Published Online: 16 MAY 2006
  2. Published Print: 27 JAN 2006

ISBN Information

Print ISBN: 9780470863046

Online ISBN: 9780470032893

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Keywords:

  • Cartesian coordinate frame;
  • macromolecular crystallography;
  • high-throughput automated crystallization robotics;
  • multiple anomalous diffraction (MAD);
  • Structure determination;
  • PROCHECK algorithm;
  • crystallography-based cancer drug discovery;
  • structural genomics;
  • molecular modelling;
  • human histone deacetylase, HDC8

Summary

This chapter contains sections titled:

  • Introduction

  • Macromolecular crystallography

  • Molecular modelling

  • Conclusions