Chapter 17. Methionine Sulfoxide: Chemistry and Biochemistry

  1. Professor Saul Patai2,
  2. Zvi Rappoport2 and
  3. Charles Stirling3
  1. Nathan Brot and
  2. Herbert Weissbach

Published Online: 3 JUL 2006

DOI: 10.1002/0470034386.ch17

Sulphones and Sulphoxides (1988)

Sulphones and Sulphoxides (1988)

How to Cite

Brot, N. and Weissbach, H. (1988) Methionine Sulfoxide: Chemistry and Biochemistry, in Sulphones and Sulphoxides (1988) (eds S. Patai, Z. Rappoport and C. Stirling), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470034386.ch17

Editor Information

  1. 2

    The Hebrew University, Jerusalem, Israel

  2. 3

    University College, Bangor, USA

Author Information

  1. Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA

Publication History

  1. Published Online: 3 JUL 2006
  2. Published Print: 30 APR 1988

Book Series:

  1. PATAI'S Chemistry of Functional Groups

Book Series Editors:

  1. Professor Saul Patai

Series Editor Information

  1. The Hebrew University, Jerusalem, Israel

ISBN Information

Print ISBN: 9780471915881

Online ISBN: 9780470034385



  • methionene sulfoxide chemistry and biochemistry;
  • methionene chemical oxidation;
  • biological oxidation of methionenes;
  • enzymatic reduction of Met(O) residues;
  • plasminogen activator inhibitor;
  • low molecular weight peptides;
  • Met(O)–peptide reductase;
  • increased synthesis of biological oxidation


This chapter contains sections titled:

  • Introduction

  • Chemical Oxidation of Methionine

  • Biological Oxidation of Methionine

  • Assay for Met(O) in Proteins

  • Presence of Met(O) in Proteins

  • Oxidized E. Coli Ribosomal Protein L12

  • Oxidation of α-1-PI

  • Enzymatic Reduction of Met(O) Residues

  • Clinical Relationship

  • References