Chapter 1. Tumor Vasculature: a Target for Anticancer Therapies

  1. Dietmar W. Siemann1,2
  1. Dietmar W. Siemann1,2

Published Online: 31 MAY 2006

DOI: 10.1002/0470035439.ch1

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology

How to Cite

Siemann, D. W. (2006) Tumor Vasculature: a Target for Anticancer Therapies, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch1

Editor Information

  1. 1

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 2

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Author Information

  1. 1

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 2

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 10 MAR 2006

ISBN Information

Print ISBN: 9780470012949

Online ISBN: 9780470035436

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Keywords:

  • tumor vasculature;
  • increased tumor cell kill;
  • tumor endothelium;
  • targeting tumor blood vessel network;
  • Vascular-targeting therapies;
  • vascular-disrupting agents (VDAs);
  • vascular targeting agents and conventional anticancer therapies;
  • conventional treatment modalities

Summary

This chapter contains sections titled:

  • Introduction

  • Tumor vasculature

  • Impact of tumor microenvironments on cancer management

  • Vascular-targeting therapies

  • Combinations with conventional anticancer therapies

  • Combinations of antiangiogenic and vascular-disrupting agents

  • Conclusions

  • Acknowledgments

  • References