Chapter 10. Targeting Inside-Out Phospholipids on Tumor Blood Vessels in Pancreatic Cancer

  1. Dietmar W. Siemann5,6
  1. Adam W. Beck1,
  2. Rolf A. Brekken2,3 and
  3. Philip E. Thorpe4

Published Online: 31 MAY 2006

DOI: 10.1002/0470035439.ch10

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology

How to Cite

Beck, A. W., Brekken, R. A. and Thorpe, P. E. (2006) Targeting Inside-Out Phospholipids on Tumor Blood Vessels in Pancreatic Cancer, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch10

Editor Information

  1. 5

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 6

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Author Information

  1. 1

    5323 Harry Hines Boulevard, MC 8593, Dallas, TX 75390, USA

  2. 2

    Departments of Surgery and Pharmacology, Southwestern Medical Center, NB8.218a, 6000 Harry Hines Boulevard, Dallas, TX 75390-8593, USA

  3. 3

    Hamon Center for Thearpeutic Oncology Research UT, Southwestern Medical Center, NB8.218a, 6000 Harry Hines Boulevard, Dallas, TX 75390-8593, USA

  4. 4

    Department of Pharmacology, University of Texas, Southwestern Medical Center, 2201 Inwood Road, NC7.304, Dallas, TX 75390-8594, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 10 MAR 2006

ISBN Information

Print ISBN: 9780470012949

Online ISBN: 9780470035436

SEARCH

Keywords:

  • vascular targeting;
  • Vascular-targeting agents (VTAs);
  • inside-out phospholipids in pancreatic cancer;
  • pancreatic adenocarcinoma;
  • Phosphatidylserine (PS) - anionic phospholipid;
  • PS exposure on tumor endothelium;
  • combination therapy on metastasis;
  • enhanced antitumor effect of combination therapy

Summary

This chapter contains sections titled:

  • Vascular targeting

  • Pancreatic cancer: the clinical need

  • Phosphatidylserine

  • Proof of concept studies

  • Combined treatment with 3G4 and gemcitabine in a pancreatic cancer model

  • Mechanism of action

  • Conclusion

  • References