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Chapter 11. Cadherin Antagonists as Vasculature-targeting Agents

  1. Dietmar W. Siemann3,4
  1. Orest W. Blaschuk1,
  2. Tracey M. Rowlands2

Published Online: 31 MAY 2006

DOI: 10.1002/0470035439.ch11

Book Title

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology

Additional Information

How to Cite

Blaschuk, O. W. and Rowlands, T. M. (2006) Cadherin Antagonists as Vasculature-targeting Agents, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch11

Editor Information

  1. 3

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 4

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Author Information

  1. 1

    Urology Research Laboratories, Room H6.15, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada

  2. 2

    Adherex Technologies Inc., Research Triangle Park, Durham, NC 27713, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 10 MAR 2006

ISBN Information

Print ISBN: 9780470012949

Online ISBN: 9780470035436

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CHAPTER TOOLS

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Keywords:

  • Vascular endothelial (VE)- and neural (N)-cadherins;
  • cadherin antagonists;
  • cadherins and vasculature;
  • tumor vasculature;
  • cadherin antagonists - vascular targeting agents;
  • blocking angiogenesis and slowing tumor growth;
  • ADH-1 effects on pericytes;
  • pericyte regulator of blood vessel stability

Summary

This chapter contains sections titled:

  • Pericytes as regulators of blood vessel stability

  • Cadherins

  • Cadherins and the vasculature

  • Tumor vasculature

  • Manipulation of the tumor vasculature with cadherin antagonists

  • Summary and future directions

  • Acknowledgment

  • References

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