Chapter 14. Development of Vasculature-targeted Cancer Gene Therapy

  1. Dietmar W. Siemann3,4
  1. Graeme J. Dougherty1,
  2. Peter D. Davis2 and
  3. Shona T. Dougherty1

Published Online: 31 MAY 2006

DOI: 10.1002/0470035439.ch14

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology

How to Cite

Dougherty, G. J., Davis, P. D. and Dougherty, S. T. (2006) Development of Vasculature-targeted Cancer Gene Therapy, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch14

Editor Information

  1. 3

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 4

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Author Information

  1. 1

    Department of Radiation Oncology, Arizona Cancer Center, 1501 North Campbell Avenue, P.O. Box 245081, Tucson, AZ 85724-5081, USA

  2. 2

    Angiogene Pharmaceuticals Ltd., The Magdalen Centre, The Oxford Science Park, Oxfordshire OX9 5SX, UK

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 10 MAR 2006

ISBN Information

Print ISBN: 9780470012949

Online ISBN: 9780470035436



  • vascular-targeted cancer gene therapy;
  • tumor vasculature in cancer gene therapy;
  • targeting gene therapy to tumor vasculature;
  • transductional targeting;
  • functional targeting;
  • transcriptional targeting;
  • post-transcriptional targeting;
  • tumor-cell-directed gene therapy and tumor vasculature


This chapter contains sections titled:

  • Introduction

  • Advantages of tumor vasculature as a target in cancer gene therapy

  • Genes of value in vascular-targeted cancer gene therapy

  • Targeting gene therapy to tumor vasculature

  • Concluding remarks

  • Acknowledgment

  • References