Chapter 15. Vasculature-disrupting Strategies Combined with Bacterial Spores Targeting Hypoxic Regions of Solid Tumors
- Dietmar W. Siemann2,3
Published Online: 31 MAY 2006
DOI: 10.1002/0470035439.ch15
Copyright © 2006 John Wiley & Sons, Ltd
Book Title
Vascular-Targeted Therapies in Oncology
Additional Information
How to Cite
Ahn, G.-O. and Brown, J. M. (2006) Vasculature-disrupting Strategies Combined with Bacterial Spores Targeting Hypoxic Regions of Solid Tumors, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch15
Editor Information
- 2
Shands Cancer Center, University of Florida, Gainsville, Florida, USA
- 3
Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA
Publication History
- Published Online: 31 MAY 2006
- Published Print: 10 MAR 2006
ISBN Information
Print ISBN: 9780470012949
Online ISBN: 9780470035436
- Summary
- Chapter
Keywords:
- vascular disrupting agents and genetically engineered anaerobic bacteria;
- hypoxic/necrotic area and human solid tumor;
- vasculature-disrupting strategies;
- clostridia as hypoxia/necrotic selective cancer therapy;
- optimizing prodrug design;
- ADEPT (antibody-directed) and GDEPT (gene-directed);
- clostridial approach to enzyme/prodrug therapy (CDEPT);
- CDEPT and vascular-disrupting agents;
- CDEPT in combination with DMXAA
Summary
This chapter contains sections titled:
Hypoxia and necrosis as a selective target for cancer therapy
Use of Clostridia as hypoxia/necrotic selective cancer therapy
Advantage of CDEPT over ADEPT and GDEPT
Combination of CDEPT with vascular-disrupting agents
Clinical significance
References