Chapter 2. Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors
- Dietmar W. Siemann2,3
Published Online: 31 MAY 2006
DOI: 10.1002/0470035439.ch2
Copyright © 2006 John Wiley & Sons, Ltd
Book Title
Vascular-Targeted Therapies in Oncology
Additional Information
How to Cite
Vaupel, P. (2006) Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch2
Editor Information
- 2
Shands Cancer Center, University of Florida, Gainsville, Florida, USA
- 3
Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA
Publication History
- Published Online: 31 MAY 2006
- Published Print: 10 MAR 2006
ISBN Information
Print ISBN: 9780470012949
Online ISBN: 9780470035436
- Summary
- Chapter
Keywords:
- tumor microvasculature;
- microvasculature in solid tumors;
- tumor angiogenesis - vascular endothelial growth factor (VEGF);
- tumor vascularity and blood flow;
- tumor lymphangiogenesis;
- tumor-to-tumor variability;
- tumor interstitial space volume and composition;
- diffusion limited hypoxia;
- ‘crucial Ps’ in tumors
Summary
This chapter contains sections titled:
Introduction
Basic principles of blood vessel formation in tumors
Tumor lymphangiogenesis
Tumor vascularity and blood flow
Volume and composition of the tumor interstitial space
Fluid pressure and convective currents in the interstitial space of tumors
Evidence, characterization and pathogenesis of tumor hypoxia
Tumor pH
The ‘crucial Ps’ characterizing the hostile metabolic microenvironment of solid tumors
Acknowledgment
References