Chapter 2. Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors

  1. Dietmar W. Siemann2,3
  1. Peter Vaupel

Published Online: 31 MAY 2006

DOI: 10.1002/0470035439.ch2

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology

How to Cite

Vaupel, P. (2006) Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch2

Editor Information

  1. 2

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 3

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Author Information

  1. Institute of Physiology and Pathophysiology, University of Mainz, Düsbergweg 6, 55099 Mainz, Germany

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 10 MAR 2006

ISBN Information

Print ISBN: 9780470012949

Online ISBN: 9780470035436



  • tumor microvasculature;
  • microvasculature in solid tumors;
  • tumor angiogenesis - vascular endothelial growth factor (VEGF);
  • tumor vascularity and blood flow;
  • tumor lymphangiogenesis;
  • tumor-to-tumor variability;
  • tumor interstitial space volume and composition;
  • diffusion limited hypoxia;
  • ‘crucial Ps’ in tumors


This chapter contains sections titled:

  • Introduction

  • Basic principles of blood vessel formation in tumors

  • Tumor lymphangiogenesis

  • Tumor vascularity and blood flow

  • Volume and composition of the tumor interstitial space

  • Fluid pressure and convective currents in the interstitial space of tumors

  • Evidence, characterization and pathogenesis of tumor hypoxia

  • Tumor pH

  • The ‘crucial Ps’ characterizing the hostile metabolic microenvironment of solid tumors

  • Acknowledgment

  • References