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Chapter 3. The Role of Microvasculature in Metastasis Formation

  1. Dietmar W. Siemann3,4
  1. Oliver Stoeltzing1,
  2. Lee M. Ellis2

Published Online: 31 MAY 2006

DOI: 10.1002/0470035439.ch3

Book Title

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology

Additional Information

How to Cite

Stoeltzing, O. and Ellis, L. M. (2006) The Role of Microvasculature in Metastasis Formation, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch3

Editor Information

  1. 3

    Shands Cancer Center, University of Florida, Gainsville, Florida, USA

  2. 4

    Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA

Author Information

  1. 1

    Departments of Surgery and Experimental Surgery, University of Regensburg, Franz-Josef Strauss Allee 11, 93053 Regensburg, Germany

  2. 2

    Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, 1400 Holcombe Boulevard, FC12.3056, P.O. Box 301402, Houston, TX 77230-1402, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 10 MAR 2006

ISBN Information

Print ISBN: 9780470012949

Online ISBN: 9780470035436

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CHAPTER TOOLS

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Keywords:

  • tumour angiogenesis and metastases formation;
  • tumor cell proliferation in primary lesion;
  • extensive vascularization network;
  • extracellular matrix (ECM) invasion;
  • ‘organ-site’ specific neoplastic microvasculature;
  • microvasculature role in metastasis formation;
  • VEGF and tumour angiogenesis;
  • hypoxia-inducible factor-1 α;
  • angiogenesis regulator in solid tumors;
  • targeting neoplastic microvasculature

Summary

This chapter contains sections titled:

  • Introduction

  • Regulators of angiogenesis in solid tumors

  • Angiogenesis and metastasis formation

  • Summary

  • References

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