Chapter 6. Molecular Recognition of the Colchicine Binding Site as a Design Paradigm for the Discovery and Development of Vascular Disrupting Agents
- Dietmar W. Siemann2,3
Published Online: 31 MAY 2006
DOI: 10.1002/0470035439.ch6
Copyright © 2006 John Wiley & Sons, Ltd
Book Title
Vascular-Targeted Therapies in Oncology
Additional Information
How to Cite
Pinney, K. G. (2006) Molecular Recognition of the Colchicine Binding Site as a Design Paradigm for the Discovery and Development of Vascular Disrupting Agents, in Vascular-Targeted Therapies in Oncology (ed D. W. Siemann), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470035439.ch6
Editor Information
- 2
Shands Cancer Center, University of Florida, Gainsville, Florida, USA
- 3
Research Department of Radiation Oncology, University of Florida, 2000 RW Archer Road, Gainsville, FL 32610, USA
Publication History
- Published Online: 31 MAY 2006
- Published Print: 10 MAR 2006
ISBN Information
Print ISBN: 9780470012949
Online ISBN: 9780470035436
- Summary
- Chapter
Keywords:
- successful molecular architecture;
- tubulin/microtubule protein system - drug intervention target;
- vascular disruption;
- molecular recognition of colchicine binding site;
- colchicine binding site on tubulin;
- small-molecule inhibitor of tubulin assembly;
- vascular disruption therapy;
- small-molecule VDAs in phase I, Ib and II clinical trials
Summary
This chapter contains sections titled:
Introductory comments
Colchicine binding site on tubulin
Brief overview of tubulin biology
Small-molecule inhibitors of tubulin assembly
Design paradigm for small-molecule vascular disrupting agents
Concluding remarks
Acknowledgments
References