Chapter 16. Energy and Entropy Effects in Gas-Phase Dissociation of Peptides and Proteins

  1. Julia Laskin PhD1 and
  2. Chava Lifshitz PhD2
  1. Julia Laskin PhD

Published Online: 6 MAR 2006

DOI: 10.1002/047005042X.ch16

Principles of Mass Spectrometry Applied to Biomolecules

Principles of Mass Spectrometry Applied to Biomolecules

How to Cite

Laskin, J. (2006) Energy and Entropy Effects in Gas-Phase Dissociation of Peptides and Proteins, in Principles of Mass Spectrometry Applied to Biomolecules (eds J. Laskin and C. Lifshitz), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/047005042X.ch16

Editor Information

  1. 1

    Fundamental Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999 K8-88, Richland, WA 99352, USA

  2. 2

    Department of Physical Chemistry and The Farkas Center for Light Induced Processes, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

Author Information

  1. Fundamental Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999 K8-88, Richland, WA 99352, USA

Publication History

  1. Published Online: 6 MAR 2006
  2. Published Print: 16 OCT 2006

ISBN Information

Print ISBN: 9780471721840

Online ISBN: 9780470050422

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Keywords:

  • polyatomic molecule dissociation;
  • energy and entropy effects in gas-phase;
  • Blackbody Infrared Radiative Dissociation (BIRD)

Summary

This chapter contains sections titled:

  • Introduction

  • Dissociation of Polyatomic Molecules

  • Historical Overview of Experimental Methods for Measuring Threshold Energies and Activation Entropies

  • Why It Is Difficult to Determine Dissociation Parameters for Biomolecules

  • Surface-Induced Dissociation of Peptides

  • Blackbody Infrared Radiative Dissociation (BIRD)

  • Comparison with Entropy Effects in Protein Association Reactions

  • Concluding Remarks

  • Acknowledgments

  • References