Mouse and Hamster Models for the Study of Therapy against Flavivirus Infections

  1. Gregory Bock Organizer and
  2. Jamie Goode
  1. Nathalie Charlier1,2,
  2. Erik De Clercq1 and
  3. Johan Neyts1,3

Published Online: 7 OCT 2008

DOI: 10.1002/0470058005.ch16

New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277

New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277

How to Cite

Charlier, N., Clercq, E. D. and Neyts, J. (2008) Mouse and Hamster Models for the Study of Therapy against Flavivirus Infections, in New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470058005.ch16

Author Information

  1. 1

    Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Minderbroedersstraat, 10, B-3000 Leuven, Belgium

  2. 2

    University of Leuven, Rega Institute of Medical Research, Laboratory of Virology, Minderbroedersstraat 10, B-3000 Leuven, Belgium

  3. 3

    Rega Institute for Medical Research, Department of Chemotherapy, K. U. Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Publication History

  1. Published Online: 7 OCT 2008
  2. Published Print: 25 AUG 2006

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470016435

Online ISBN: 9780470058008

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Keywords:

  • flavivirus;
  • animal model;
  • mouse;
  • hamster

Summary

Small animal models that are reminiscent of flaviviral disease in human will be instrumental in identifying therapeutic strategies against flavivirus infections. Here we review models in mice and hamsters for the most clinically important flaviviruses: dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus and tick-borne encephalitis virus. In addition, models are discussed that employ no known vector viruses such as the Modoc virus. These viruses can be manipulated in BSL-2 laboratories and in infected mice and hamsters they mimic flaviviral disease in human.