This paper was presented at the symposium by Richard J. Kuhn, to whom correspondence should be addressed.
Development of Novel Antivirals against Flaviviruses
- Gregory Bock Organizer,
- Jamie Goode
Published Online: 7 OCT 2008
DOI: 10.1002/0470058005.ch4
Copyright © Novartis Foundation 2006
Book Title
New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277
Additional Information
How to Cite
Patkar, C. G. and Kuhn, R. J. (2008) Development of Novel Antivirals against Flaviviruses, in New Treatment Strategies for Dengue and Other Flaviviral Diseases: Novartis Foundation Symposium 277 (eds G. Bock and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/0470058005.ch4
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This paper was presented at the symposium by Richard J. Kuhn, to whom correspondence should be addressed.
Publication History
- Published Online: 7 OCT 2008
- Published Print: 25 AUG 2006
ISBN Information
Print ISBN: 9780470016435
Online ISBN: 9780470058008
- Summary
- Chapter
Keywords:
- dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS);
- structure-based drug design and informative biochemical assays;
- flavivirus replicon system construction;
- flavivirus antivirals;
- flavivirus E protein
Summary
Dengue virus is responsible for a significant amount of human disease in predominantly tropical areas of the world. Much effort has focused on the development of vaccines against the four serotypes of dengue, and within the next few years a vaccine is anticipated. Less progress has been made at developing antivirals that might reduce disease severity. Recent advances in the structural biology of dengue virus and other flaviviruses have opened new possibilities for the rational design of small molecule inhibitors of virus replication. This chapter describes the structural attributes of the dengue virion and how knowledge of its structure, assembly, and entry mechanisms are guiding new strategies toward the development of compounds that will interfere with the viral replication process.